2024 Author: Jasmine Walkman | [email protected]. Last modified: 2023-12-16 08:29
Excessive consumption of grapefruit or grapefruit juice can lead to some harmful effects on human health. Grapefruit juice, as well as the fruit itself, can cause side effects if taken with certain medications. They can be dangerous if taken in combination with medicines for blood pressure and medicines that improve digestion. Depending on the type and dose of medication taken, it may be necessary to limit or even stop grapefruit intake altogether, even in small amounts.
Consumption of grapefruit can lower blood pressure and reduce heart rate. Symptoms that may occur with side effects of drugs and grapefruit are: slow heart rate, rapid heartbeat, which can lead to sudden death, rhabdomyolysis (serious damage to skeletal muscle, which can lead to kidney damage)., nephrotoxicity (kidney damage), myeloma toxicity (bone marrow damage).
The drugs with which grapefruit interacts are as follows:
1. Anti-cancer: dasatinib (leukemia); Erlotinib (lung cancer and pancreatic cancer); everolimus (kidney cancer); lapatinib (breast cancer); nilotinib (leukemia); pazopanib (kidney cancer); sunitinib (kidney / gastrointestinal cancer); vandetanib (thyroid cancer); Venurafenib (skin cancer).
2. Anti-infectious: erythromycin (antibiotic); halofantrine (malaria); maraviroc (HIV); primacoin (malaria); quinine (malaria); rilpivirine (HIV).
3. Anti-cholesterol: Atorvastatin; Lovastatin; Simvastatin.
4. Cardiovascular: (heart rhythm disorders) amiodarone; apixaban (anti-coagulation); (heart rhythm disorders) Dronedarone; Eplerenone (heart failure); felodipine (high blood pressure / angina); Nifedipine (high blood pressure / angina); quinidine (heart rhythm disorder); rivaroxaban (anti-blood clotting).
5. Central nervous system: Oral alfentalin (painkillers); analgesic; oxycodone (painkillers); pimozide (schizophrenia / other mental health problems); Ziprasidone (schizophrenia, mania, bipolar disorder).
6. Gastrointestinal: Domperidone (anti-nausea); Cyclosporine (after organ transplantation, rheumatoid arthritis, psoriasis); Tacrolimus (after transplantation).
7. Urinary: silodosin (prostate enlargement); tamsulosin (prostate enlargement).
One grapefruit contains about 100 calories. Excessive consumption can lead to obesity, as it is high in natural sugars. For this reason, if taken with vegetables, it is more stimulating for weight gain. Grapefruit juice contains more fiber and less sugar. Therefore, it is recommended to consume the juice of this fruit. Dietitians should not overdo the consumption of juice, as high fiber content can lead to stomach cramps and gastrointestinal side effects such as gas and diarrhea.
Some clinical studies have shown a possible link between grapefruit consumption and an increased risk of breast cancer. Women who take grapefruit (one or more quarters of grapefruit) after menopause have a significant increased risk of breast cancer compared to consumers who do not.
The recommended dose for grapefruit juice is 1 tsp. for 12 weeks 3 times a day. This dose has a positive effect on metabolism.
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